Premature Ejaculation Cheapest viagra without prescription canadian viagra for sale online What causes premature ejaculation?nal and physical factors can lead to premature ejaculation. It may happen when a man becomes too excited or stimulated, or if his penis is very sensitive. It may also happen if a man is nervous or uncomfortable with a new partner. Other common causes include the following: Neurological exam Men usually experience erectile dysfunction more than three years before coronary heart disease rears it head. Diabetes, erectile dysfunction, and heart disease are all related to damage of the blood vessels caused by high blood sugar levels. Men should be aware that if the blood flow required for maintaining an erection isn't happening, this could mean even more severe consequences for the heart. Hormonal imbalances: Imbalances of hormones, such as thyroid hormones, prolactin, and testosterone, can affect a man's response to sexual stimulation. These imbalances can be the result of a tumor of the pituitary gland, kidney disease, liver disease, or hormonal treatment of prostate cancer.